The actor, 57, was gushed over in the special edition by his co-star Carrie-Anne Moss, 54.
She said in an essay for the magazine: “In this often unkind and shallow world, my friend Keanu gives others hope.”
The actress, who played Trinity alongside Reeves in The Matrix films, added he was far from other celebrities who proved a let down off-screen.
She added: “The actions of this handsome, talented, successful, and fiercely committed actor have become a reprieve from the constant disappointment we have for those who get put on a pedestal.”
Moss also called Reeves’ fame “unique” and said he is renowned for “his kindness and generosity”.
The pair first worked together on 1999’s The Matrix before reprising their roles three times in follow-ups, with the most recent outing in December.
Moss said about their first meeting: “Keanu was just as he always is: kind, generous, and thoughtful… [he is] still the man who checks in on me during an intense training day just as he did then.”
Keanu, worth an estimated NZ$640 million, has given away chunks of his fortune over the years as part of good deeds.
He runs a private foundation that benefits cancer research and children’s hospitals, gifted the stunt crew on ‘The Matrix’ a motorcycle each, and bought his mum a house.
Among the other famous faces listed in the 100 most influential people issue are Kris Jenner, 66, actress Mila Kunis, 38, and comedian Pete Davidson, 28, who has been dating Kris’ daughter Kim, 41, since November 2021.
Each of those listed has a tribute written about them by a peer or colleague.
Zendaya, 25, was one of five celebrities to get her own cover for this issue.
The others went to singer Mary J Blige, 51, actor Simu Liu, 33, Prime Minister of Barbados Mia Mottley, 56, and chief executive officer of Apple Tim Cook, 61.